One of the advantages of organizing anatomy and physiology concepts into short, modular chapters is that it gives us more flexibility in teaching. It also permits us to focus on important topics that are often buried within a large chapter that covers many subtopics. Taking this advantage, Anatomy & Physiology puts the clinically important concepts of stress into a single, independent chapter.The concepts of stress interconnect with concepts of neuroscience, endocrinology, immunology, and many others—covered in diverse chapters of a textbook and diverse modules of an A&P course. Putting the core concepts of stress into its own independent chapter means that the instructor has more flexibility in where they place in their own course structure—into their own unique telling of the story of the human body.Our book was the first A&P textbook to have an independent stress chapter. Since its introduction, we’ve been keeping the content up to date and relevant to student learning—and to the clinical applications of stress they’ll be making in their professional courses and careers. More recently, we enlisted the advice of the late Dr. Bruce McEwen, an icon of the modern concepts of human stress and it’s real-life implications. Contributing author Dr. Peggie Williamson and I used Bruce’s advice and his generous stack of resources to give our stress chapter a major refresh and update. You will find that the engaging story-of-stress approach remains, but with the more recent parts of that story reflected with greater clarity and relevance.We need not let the concepts of stress be stressors themselves in our teaching and learning. Using the stress chapter in Anatomy & Physiology—a reader favorite—can help us all better understand the pivotal role stress can have in wellness and disease.